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5C3H

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 1

Summary for 5C3H
Entry DOI10.2210/pdb5c3h/pdb
Related5C0K
DescriptorE3 ubiquitin-protein ligase XIAP, ZINC ION, 4-[2-oxo-2-(piperidin-1-yl)ethyl]piperazin-1-ium, ... (4 entities in total)
Functional Keywordsapoptosis, ligase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P98170
Total number of polymer chains1
Total formula weight12963.93
Authors
Primary citationChessari, G.,Buck, I.M.,Day, J.E.,Day, P.J.,Iqbal, A.,Johnson, C.N.,Lewis, E.J.,Martins, V.,Miller, D.,Reader, M.,Rees, D.C.,Rich, S.J.,Tamanini, E.,Vitorino, M.,Ward, G.A.,Williams, P.A.,Williams, G.,Wilsher, N.E.,Woolford, A.J.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58:6574-6588, 2015
Cited by
PubMed: 26218264
DOI: 10.1021/acs.jmedchem.5b00706
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

數據於2024-03-27公開中

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