5C20
Crystal structure of EV71 3C Proteinase in complex with Compound 2
Summary for 5C20
Entry DOI | 10.2210/pdb5c20/pdb |
Related | 4GHQ 4GHT 5C1U 5C1X 5C1Y |
Descriptor | 3C proteinase, 2-methylpropyl N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate (3 entities in total) |
Functional Keywords | hydrolase, cysteine proteinase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Enterovirus A71 |
Total number of polymer chains | 1 |
Total formula weight | 21796.97 |
Authors | |
Primary citation | Zhang, L.,Huang, G.,Cai, Q.,Zhao, C.,Tang, L.,Ren, H.,Li, P.,Li, N.,Huang, J.,Chen, X.,Guan, Y.,You, H.,Chen, S.,Li, J.,Lin, T. Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit., 29:520-527, 2016 Cited by PubMed: 27185390DOI: 10.1002/jmr.2551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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