5BY1

H18 Bat Influenza NS1 RNA Binding Domain

5BY1 の概要

• エントリーDOI: 10.2210/pdb5by1/pdb
• 分子名称: Non-structural protein 1, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: viral protein, immune antagonist
• 由来する生物種: Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11))
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19212.25

構造登録者

Kerry, P.S.,Hale, B.G. (登録日: 2015-06-09, 公開日: 2015-08-19, 最終更新日: 2024-01-10)

主引用文献

Turkington, H.L.,Juozapaitis, M.,Kerry, P.S.,Aydillo, T.,Ayllon, J.,Garcia-Sastre, A.,Schwemmle, M.,Hale, B.G.
Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.
J.Virol., 89:10696-10701, 2015

PubMed Abstract: We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-competent cells but not in cells unable to establish antiviral immunity.

PubMed: 26246567
DOI: 10.1128/JVI.01430-15

実験手法

X-RAY DIFFRACTION (1.751 Å)