5BXT

LNBase in complex with LNB-NHAcAUS

5BXT の概要

• エントリーDOI: 10.2210/pdb5bxt/pdb
• 関連するPDBエントリー: 5BXP 5BXR 5BXS
• 分子名称: Lacto-N-biosidase, SULFATE ION, N-{[(1R,2R,3R,7S,7aR)-1,2,7-trihydroxyhexahydro-1H-pyrrolizin-3-yl]methyl}acetamide, ... (5 entities in total)
• 機能のキーワード: tim barrel, hydrolase, distal gut, human milk oligosaccharides, inhibitor
• 由来する生物種: Bifidobacterium bifidum JCM 1254
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 145085.60

構造登録者

Ito, T.,Arakawa, T.,Fushinobu, S. (登録日: 2015-06-09, 公開日: 2015-09-09, 最終更新日: 2024-11-06)

主引用文献

Hattie, M.,Ito, T.,Debowski, A.W.,Arakawa, T.,Katayama, T.,Yamamoto, K.,Fushinobu, S.,Stubbs, K.A.
Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis
Chem.Commun.(Camb.), 51:15008-15011, 2015

PubMed Abstract: The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.

PubMed: 26312778
DOI: 10.1039/c5cc05494j

実験手法

X-RAY DIFFRACTION (1.8 Å)