5BWT

X-RAY CRYSTAL STRUCTURE AT 2.20A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A PYRAZOLOPYRIMIDINONE FRAGMENT AND AN INTERNAL ALDIMINE LINKED PLP.

5BWT の概要

• エントリーDOI: 10.2210/pdb5bwt/pdb
• 分子名称: Branched-chain-amino-acid aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, 5-ethyl-2-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, ... (7 entities in total)
• 機能のキーワード: fold type iv, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84920.35

構造登録者

Somers, D.O. (登録日: 2015-06-08, 公開日: 2015-07-01, 最終更新日: 2019-06-12)

• 主引用文献: Bertrand, S.M.,Ancellin, N.,Beaufils, B.,Bingham, R.P.,Borthwick, J.A.,Boullay, A.B.,Boursier, E.,Carter, P.S.,Chung, C.W.,Churcher, I.,Dodic, N.,Fouchet, M.H.,Fournier, C.,Francis, P.L.,Gummer, L.A.,Herry, K.,Hobbs, A.,Hobbs, C.I.,Homes, P.,Jamieson, C.,Nicodeme, E.,Pickett, S.D.,Reid, I.H.,Simpson, G.L.,Sloan, L.A.,Smith, S.E.,Somers, D.O.,Spitzfaden, C.,Suckling, C.J.,Valko, K.,Washio, Y.,Young, R.J.; The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.; J.Med.Chem., 58:7140-7163, 2015; PubMed: 26090771; DOI: 10.1021/acs.jmedchem.5b00313

実験手法

X-RAY DIFFRACTION (2.2 Å)