5BQI
Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain
Summary for 5BQI
Entry DOI | 10.2210/pdb5bqi/pdb |
Descriptor | Prostaglandin E synthase, 2-(difluoromethyl)-5-{[(2-methylpropanoyl)amino]methyl}-N-{5-methyl-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine-3-carboxamide, GLUTATHIONE, ... (7 entities in total) |
Functional Keywords | mpges-1, enzyme, integral membrane protein, targetname, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18993.40 |
Authors | Fisher, M.J.,Schiffler, M.A.,Kuklish, S.L.,Antonysamy, S.,Luz, J.G. (deposition date: 2015-05-29, release date: 2016-04-13, Last modification date: 2024-03-06) |
Primary citation | Schiffler, M.A.,Antonysamy, S.,Bhattachar, S.N.,Campanale, K.M.,Chandrasekhar, S.,Condon, B.,Desai, P.V.,Fisher, M.J.,Groshong, C.,Harvey, A.,Hickey, M.J.,Hughes, N.E.,Jones, S.A.,Kim, E.J.,Kuklish, S.L.,Luz, J.G.,Norman, B.H.,Rathmell, R.E.,Rizzo, J.R.,Seng, T.W.,Thibodeaux, S.J.,Woods, T.A.,York, J.S.,Yu, X.P. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J.Med.Chem., 59:194-205, 2016 Cited by PubMed: 26653180DOI: 10.1021/acs.jmedchem.5b01249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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