5BQ0
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171 AKA 6-[(3R)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide
Summary for 5BQ0
Entry DOI | 10.2210/pdb5bq0/pdb |
Related | 5BPY |
Descriptor | Tyrosine-protein kinase BTK, 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl)carbonyl]-9H-carbazole-1-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 33329.67 |
Authors | Muckelbauer, J.K. (deposition date: 2015-05-28, release date: 2015-09-23, Last modification date: 2024-03-06) |
Primary citation | Liu, Q.,Batt, D.G.,Lippy, J.S.,Surti, N.,Tebben, A.J.,Muckelbauer, J.K.,Chen, L.,An, Y.,Chang, C.,Pokross, M.,Yang, Z.,Wang, H.,Burke, J.R.,Carter, P.H.,Tino, J.A. Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Bioorg.Med.Chem.Lett., 25:4265-4269, 2015 Cited by PubMed: 26320619DOI: 10.1016/j.bmcl.2015.07.102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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