5B6O

Crystal structure of MS8104

「2YY4」から置き換えられました

5B6O の概要

• エントリーDOI: 10.2210/pdb5b6o/pdb
• 関連するPDBエントリー: 2duc
• 分子名称: 3C-like proteinase (2 entities in total)
• 機能のキーワード: hydrolase, structural genomics, riken structural genomics/proteomics initiative, rsgi
• 由来する生物種: Human SARS coronavirus (SARS-CoV)
• 細胞内の位置: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69871.91

構造登録者

Wang, H.,Kim, Y.,Muramatsu, T.,Takemoto, C.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2016-05-31, 公開日: 2016-06-15, 最終更新日: 2023-11-08)

• 主引用文献: Muramatsu, T.,Takemoto, C.,Kim, Y.T.,Wang, H.,Nishii, W.,Terada, T.,Shirouzu, M.,Yokoyama, S.; SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity; Proc. Natl. Acad. Sci. U.S.A., 113:12997-13002, 2016; PubMed: 27799534; DOI: 10.1073/pnas.1601327113

実験手法

X-RAY DIFFRACTION (2.202 Å)