5B5T

Crystal Structure of Escherichia coli Gamma-Glutamyltranspeptidase in Complex with peptidyl phosphonate inhibitor 1b

5B5T の概要

• エントリーDOI: 10.2210/pdb5b5t/pdb
• 分子名称: Gamma-glutamyltranspeptidase large chain, Gamma-glutamyltranspeptidase small chain, (2~{S})-2-azanyl-4-[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-butan-2-yl]oxyphosphonoyl-butanoic acid, ... (5 entities in total)
• 機能のキーワード: glutathione, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli (strain K12); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119380.05

構造登録者

Wada, K.,Fukuyama, K. (登録日: 2016-05-18, 公開日: 2016-09-28, 最終更新日: 2023-11-08)

• 主引用文献: Kamiyama, A.,Nakajima, M.,Han, L.,Wada, K.,Mizutani, M.,Tabuchi, Y.,Kojima-Yuasa, A.,Matsui-Yuasa, I.,Suzuki, H.,Fukuyama, K.,Watanabe, B.,Hiratake, J.; Phosphonate-based irreversible inhibitors of human gamma-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity; Bioorg.Med.Chem., 24:5340-5352, 2016; PubMed: 27622749; DOI: 10.1016/j.bmc.2016.08.050

実験手法

X-RAY DIFFRACTION (1.7 Å)