5AR1

Crystal structure of Cdc11 from Saccharomyces cerevisiae

5AR1 の概要

• エントリーDOI: 10.2210/pdb5ar1/pdb
• 分子名称: CELL DIVISION CONTROL PROTEIN 11 (1 entity in total)
• 機能のキーワード: cell cycle, spetins, yeast, cdc11, nucleotide binding
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• 細胞内の位置: Membrane : P32458
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34611.72

構造登録者

Brausemann, A.,Gerhardt, S.,Schott, A.K.,Einsle, O.,Grosse-Berkenbusch, A.,Johnsson, N.,Gronemeyer, T. (登録日: 2015-09-23, 公開日: 2016-01-27, 最終更新日: 2024-01-10)

主引用文献

Brausemann, A.,Gerhardt, S.,Schott, A.K.,Einsle, O.,Grosse-Berkenbusch, A.,Johnsson, N.,Gronemeyer, T.
Crystal Structure of Cdc11, a Septin Subunit from Saccharomyces Cerevisiae.
J.Struct.Biol., 193:157-, 2016

PubMed Abstract: Septins are a conserved family of GTP-binding proteins that assemble into a highly ordered array of filaments at the mother bud neck in Saccharomyces cerevisiae cells. Many molecular functions and mechanisms of the septins in S. cerevisiae were already uncovered. However, structural information is only available from modeling the crystallized subunits of the human septins into the EM cryomicroscopy data of the yeast hetero-octameric septin rod. Octameric rods are the building block of septin filaments in yeast. We present here the first crystal structure of Cdc11, the terminal subunit of the octameric rod and discuss its structure in relation to its human homologues. Size exclusion chromatography analysis revealed that Cdc11 forms homodimers through its C-terminal coiled coil tail.

PubMed: 26780475
DOI: 10.1016/J.JSB.2016.01.004

実験手法

X-RAY DIFFRACTION (2.85 Å)