5AMT

Intracellular growth locus protein E

5AMT の概要

• エントリーDOI: 10.2210/pdb5amt/pdb
• 関連するPDBエントリー: 5AMU
• 分子名称: IGLE, 1,2-ETHANEDIOL, BROMIDE ION, ... (4 entities in total)
• 機能のキーワード: transport protein, bacterial secretion system, lipoprotein, igle, tssj, francisella novicida
• 由来する生物種: FRANCISELLA NOVICIDA
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29781.32

構造登録者

Robb, C.S.,Nano, F.E.,Boraston, A.B. (登録日: 2015-09-01, 公開日: 2016-10-05, 最終更新日: 2024-05-08)

主引用文献

Robb, C.S.,Nano, F.E.,Boraston, A.B.
Cloning, Expression, Purification, Crystallization and Preliminary X-Ray Diffraction Analysis of Intracellular Growth Locus E (Igle) Protein from Francisella Tularensis Subsp. Novicida.
Acta Crystallogr.,Sect.F, 66:1596-1598, 2010

PubMed Abstract: Tularaemia is an uncommon but potentially dangerous zoonotic disease caused by the bacterium Francisella tularensis. As few as ten bacterial cells are sufficient to cause disease in a healthy human, making this one of the most infectious disease agents known. The virulence of this organism is dependent upon a genetic locus known as the Francisella pathogenicity island (FPI), which encodes components of a secretion system that is related to the type VI secretion system. Here, the cloning, expression, purification and preliminary X-ray diffraction statistics of the FPI-encoded protein IglE are presented. This putative lipoprotein is required for intra-macrophage growth and is thought to be a constituent of the periplasmic portion of the type VI-like protein complex that is responsible for the secretion of critical virulence factors in Francisella.

PubMed: 21139203
DOI: 10.1107/S1744309110034378

実験手法

X-RAY DIFFRACTION (1.62 Å)