5AJR
Sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi in complex with the 1-tetrazole derivative VT-1161 ((R)-2-(2,4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl) pyridin-2-yl)propan-2-ol)
5AJR の概要
エントリーDOI | 10.2210/pdb5ajr/pdb |
分子名称 | STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (3 entities in total) |
機能のキーワード | cytochrome p450, cyp51, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane |
由来する生物種 | TRYPANOSOMA CRUZI |
細胞内の位置 | Membrane ; Single-pass membrane protein : Q7Z1V1 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 53696.78 |
構造登録者 | |
主引用文献 | Hoekstra, W.J.,Hargrove, T.Y.,Wawrzak, Z.,Da Gama Jaen Batista, D.,Da Silva, C.F.,Nefertiti, A.S.G.,Rachakonda, G.,Schotzinger, R.J.,Villalta, F.,Soeiro, M.D.N.C.,Lepesheva, G.I. Clinical Candidate Vt-1161'S Antiparasitic Effect in Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme Cyp51 from Trypanosoma Cruzi. Antimicrob.Agents Chemother., 60:1058-, 2015 Cited by PubMed: 26643331DOI: 10.1128/AAC.02287-15 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.75 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード