5AEP

Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders

5AEP の概要

• エントリーDOI: 10.2210/pdb5aep/pdb
• 分子名称: TYROSINE-PROTEIN KINASE JAK2, 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-2-carboxamide (3 entities in total)
• 機能のキーワード: transferase, protein kinase, jak2, myeloproliferative disorders, tumour cell proliferation inhibition, anti-cancer agents
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35549.78

構造登録者

Canevari, G.,Bertrand, J.,Brasca, M.G.,Nesi, M.,Amboldi, N.,Avanzi, N.,Bindi, S.,Casero, D.,Ciomei, M.,Colombo, N.,Cribioli, S.,Fachin, G.,Felder, E.R.,Galvani, A.,Isacchi, A.,Motto, I.,Panzeri, A.,Gnocchi, P.,Donati, D. (登録日: 2015-01-08, 公開日: 2015-04-29, 最終更新日: 2024-01-10)

• 主引用文献: Brasca, M.G.,Gnocchi, P.,Nesi, M.,Amboldi, N.,Avanzi, N.,Bertrand, J.,Bindi, S.,Canevari, G.,Casero, D.,Ciomei, M.,Colombo, N.,Cribioli, S.,Fachin, G.,Felder, E.R.,Galvani, A.,Isacchi, A.,Motto, I.,Panzeri, A.,Donati, D.; Novel Pyrrole Carboxamide Inhibitors of Jak2 as Potential Treatment of Myeloproliferative Disorders.; Bioorg.Med.Chem., 23:2387-, 2015; PubMed: 25882525; DOI: 10.1016/J.BMC.2015.03.059

実験手法

X-RAY DIFFRACTION (1.95 Å)