5ACM

Mcg immunoglobulin variable domain with methylene blue

5ACM の概要

• エントリーDOI: 10.2210/pdb5acm/pdb
• 関連するPDBエントリー: 5ACL
• 分子名称: MCG, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: immune system, mcg, immunoglobulin variable domain, methylene blue
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted : P01709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24083.89

構造登録者

Brumshtein, B.,Esswein, S.R.,Salwinski, L.,Phillips, M.L.,Ly, A.T.,Cascio, D.,Sawaya, M.R.,Eisenberg, D.S. (登録日: 2015-08-17, 公開日: 2015-12-02, 最終更新日: 2024-11-20)

主引用文献

Brumshtein, B.,Esswein, S.R.,Salwinski, L.,Phillips, M.L.,Ly, A.T.,Cascio, D.,Sawaya, M.R.,Eisenberg, D.S.
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4:e10935-e10935, 2015

PubMed Abstract: Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the amyloid state. The dimers therefore must disassociate into monomers prior to forming amyloid fibrils. Here we identify ligands that inhibit amyloid formation by stabilizing the Mcg light chain variable domain dimer and shifting the equilibrium away from the amyloid-prone monomer.

PubMed: 26576950
DOI: 10.7554/eLife.10935

実験手法

X-RAY DIFFRACTION (1.05 Å)