5AA9

Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

5AA9 の概要

• エントリーDOI: 10.2210/pdb5aa9/pdb
• 関連するPDBエントリー: 5A9U 5AA8 5AAA 5AAB 5AAC
• 分子名称: ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (3 entities in total)
• 機能のキーワード: transferase, receptor tyrosine kinase, inhibitor, mutant
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37349.78

構造登録者

McTigue, M.,Deng, Y.-L.,Liu, W.,Brooun, A.,Stewart, A. (登録日: 2015-07-23, 公開日: 2016-06-08, 最終更新日: 2024-01-10)

• 主引用文献: Shaw, A.T.,Friboulet, L.,Leshchiner, I.,Gainor, J.F.,Bergqvist, S.,Brooun, A.,Burke, B.J.,Deng, Y.,Liu, W.,Dardaei, L.,Frias, R.L.,Schultz, K.R.,Logan, J.,James, L.P.,Smeal, T.,Timofeevski, S.,Katayama, R.,Iafrate, A.J.,Le, L.,Mctigue, M.,Getz, G.,Johnson, T.W.,Engelman, J.A.; Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.; N.Engl.J.Med., 374:54-, 2016; PubMed: 26698910; DOI: 10.1056/NEJMOA1508887

実験手法

X-RAY DIFFRACTION (1.93 Å)