5AA8
Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
Summary for 5AA8
Entry DOI | 10.2210/pdb5aa8/pdb |
Related | 5A9U 5AA9 5AAA 5AAB 5AAC |
Descriptor | ALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (3 entities in total) |
Functional Keywords | transferase, receptor tyrosine kinase, inhibitor, mutant |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 37409.82 |
Authors | McTigue, M.,Deng, Y.-L.,Liu, W.,Brooun, A.,Stewart, A. (deposition date: 2015-07-23, release date: 2016-06-08, Last modification date: 2024-01-10) |
Primary citation | Shaw, A.T.,Friboulet, L.,Leshchiner, I.,Gainor, J.F.,Bergqvist, S.,Brooun, A.,Burke, B.J.,Deng, Y.,Liu, W.,Dardaei, L.,Frias, R.L.,Schultz, K.R.,Logan, J.,James, L.P.,Smeal, T.,Timofeevski, S.,Katayama, R.,Iafrate, A.J.,Le, L.,Mctigue, M.,Getz, G.,Johnson, T.W.,Engelman, J.A. Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med., 374:54-, 2016 Cited by PubMed: 26698910DOI: 10.1056/NEJMOA1508887 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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