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5A9U

Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

Summary for 5A9U
Entry DOI10.2210/pdb5a9u/pdb
Related5AA8 5AA9 5AAA 5AAB 5AAC
DescriptorALK TYROSINE KINASE RECEPTOR, (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (3 entities in total)
Functional Keywordstransferase, receptor tyrosine kinase, anaplastic lymphoma kinase, inhibitor, mutant
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight37375.80
Authors
McTigue, M.,Deng, Y.-L.,Liu, W.,Brooun, A.,Stewart, A. (deposition date: 2015-07-22, release date: 2016-06-08, Last modification date: 2024-01-10)
Primary citationShaw, A.T.,Friboulet, L.,Leshchiner, I.,Gainor, J.F.,Bergqvist, S.,Brooun, A.,Burke, B.J.,Deng, Y.,Liu, W.,Dardaei, L.,Frias, R.L.,Schultz, K.R.,Logan, J.,James, L.P.,Smeal, T.,Timofeevski, S.,Katayama, R.,Iafrate, A.J.,Le, L.,Mctigue, M.,Getz, G.,Johnson, T.W.,Engelman, J.A.
Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F.
N.Engl.J.Med., 374:54-, 2016
Cited by
PubMed: 26698910
DOI: 10.1056/NEJMOA1508887
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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