5A93

293K Joint X-ray Neutron with Cefotaxime: EXPLORING THE MECHANISM OF BETA-LACTAM RING PROTONATION IN THE CLASS A BETA-LACTAMASE ACYLATION MECHANISM USING NEUTRON AND X-RAY CRYSTALLOGRAPHY

5A93 の概要

• エントリーDOI: 10.2210/pdb5a93/pdb
• 関連するPDBエントリー: 5A90 5A91 5A92
• 分子名称: BETA-LACTAMASE CTX-M-97, CEFOTAXIME, C3' cleaved, open, bound form, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, joint neutron x-ray, beta lactamase
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28995.50

構造登録者

Vandavasi, V.G.,Weiss, K.L.,Cooper, J.B.,Erskine, P.T.,Tomanicek, S.J.,Ostermann, A.,Schrader, T.E.,Ginell, S.L.,Coates, L. (登録日: 2015-07-17, 公開日: 2015-12-16, 最終更新日: 2024-01-10)

• 主引用文献: Vandavasi, V.G.,Weiss, K.L.,Cooper, J.B.,Erskine, P.T.,Tomanicek, S.J.,Ostermann, A.,Schrader, T.E.,Ginell, S.L.,Coates, L.; Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography.; J.Med.Chem., 59:474-, 2016; PubMed: 26630115; DOI: 10.1021/ACS.JMEDCHEM.5B01215

実験手法

NEUTRON DIFFRACTION (2.2 Å)
X-RAY DIFFRACTION (1.598 Å)