5A4K

Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase

5A4K の概要

• エントリーDOI: 10.2210/pdb5a4k/pdb
• 分子名称: NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: nqo1, fad, flavoprotein, oxidative stress, quinone reductase, drug metabolism, oxidoreductase, single amino acid exchange
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P15559
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135992.62

構造登録者

Lienhart, W.D.,Strandback, E.,Gudipati, V.,Uhl, M.K.,Rantase, D.M.,Zangger, K.,Gruber, K.,Macheroux, P. (登録日: 2015-06-10, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Lienhart, W.D.,Strandback, E.,Gudipati, V.,Koch, K.,Binter, A.,Uhl, M.K.,Rantasa, D.M.,Bourgeois, B.,Madl, T.,Zangger, K.,Gruber, K.,Macheroux, P.; Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).; FEBS J., 284:1233-1245, 2017; PubMed: 28236663; DOI: 10.1111/febs.14051

実験手法

X-RAY DIFFRACTION (2.093 Å)