5A0E

Crystal structure of cyclophilin D in complex with CsA analogue, JW47.

5A0E の概要

• エントリーDOI: 10.2210/pdb5a0e/pdb
• 分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL, JW47 (3 entities in total)
• 機能のキーワード: isomerase, cyclophilin d, cyp d, ppif, cyclosporin a, csa, jw47, mitochondrial permeability transition pore, ptp, peptidylprolyl cis-trans isomerase, cyclophilin
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 38232.07

構造登録者

Warne, J.,Pryce, G.,Hill, J.,Shi, X.,Lenneras, F.,Puentes, F.,Kip, M.,Hilditch, L.,Walker, P.,Simone, M.,Chan, A.W.E.,Towers, G.,Coker, A.R.,Duchen, M.,Szabadkai, G.,Baker, D.,Selwood, D.L. (登録日: 2015-04-19, 公開日: 2015-12-30, 最終更新日: 2024-01-10)

• 主引用文献: Warne, J.,Pryce, G.,Hill, J.,Shi, X.,Lenneras, F.,Puentes, F.,Kip, M.,Hilditch, L.,Walker, P.,Simone, M.I.,Chan, A.W.E.,Towers, G.J.,Coker, A.R.,Duchen, M.R.,Szabadkai, G.,Baker, D.,Selwood, D.L.; Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis.; J.Biol.Chem., 291:4356-, 2016; PubMed: 26679998; DOI: 10.1074/JBC.M115.700385

実験手法

X-RAY DIFFRACTION (1.25 Å)