4ZXX
FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide
Summary for 4ZXX
Entry DOI | 10.2210/pdb4zxx/pdb |
Related | 4ZXY |
Descriptor | Coagulation factor VIIa heavy chain, Coagulation factor VIIa light chain, N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide, ... (6 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35048.07 |
Authors | |
Primary citation | Priestley, E.S.,Cheney, D.L.,DeLucca, I.,Wei, A.,Luettgen, J.M.,Rendina, A.R.,Wong, P.C.,Wexler, R.R. Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors. J.Med.Chem., 58:6225-6236, 2015 Cited by PubMed: 26151189DOI: 10.1021/acs.jmedchem.5b00788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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