4ZX3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b

4ZX3 の概要

• エントリーDOI: 10.2210/pdb4zx3/pdb
• 関連するPDBエントリー: 3EBG 4ZW3 4ZW5 4ZW6 4ZW7 4ZW8 4ZX4 4ZX5 4ZX6
• 分子名称: M1 family aminopeptidase, ZINC ION, N-[(1R)-1-(4-bromophenyl)-2-(hydroxyamino)-2-oxoethyl]-2,2-dimethylpropanamide, ... (6 entities in total)
• 機能のキーワード: m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 104360.19

構造登録者

Drinkwater, N.,McGowan, S. (登録日: 2015-05-20, 公開日: 2016-03-30, 最終更新日: 2023-09-27)

• 主引用文献: Drinkwater, N.,Vinh, N.B.,Mistry, S.N.,Bamert, R.S.,Ruggeri, C.,Holleran, J.P.,Loganathan, S.,Paiardini, A.,Charman, S.A.,Powell, A.K.,Avery, V.M.,McGowan, S.,Scammells, P.J.; Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.; Eur.J.Med.Chem., 110:43-64, 2016; PubMed: 26807544; DOI: 10.1016/j.ejmech.2016.01.015

実験手法

X-RAY DIFFRACTION (2 Å)