4ZX1
Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
Summary for 4ZX1
Entry DOI | 10.2210/pdb4zx1/pdb |
Related | 4ZWX 4ZWY 4ZWZ 4ZX0 |
Descriptor | Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase ix mimic, glucosyl sulfamate, inhibitor complex., lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29513.62 |
Authors | Mahon, B.P.,Lomelino, C.L.,Salguero, A.L.,McKenna, R. (deposition date: 2015-05-20, release date: 2015-10-28, Last modification date: 2024-03-06) |
Primary citation | Mahon, B.P.,Lomelino, C.L.,Moeker, J.,Rankin, G.M.,Driscoll, J.M.,Salguero, A.L.,Pinard, M.A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.,McKenna, R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates J. Med. Chem., 58:6630-6638, 2015 Cited by PubMed: 26203869DOI: 10.1021/acs.jmedchem.5b00845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.501 Å) |
Structure validation
Download full validation report