4ZWZ
Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
Summary for 4ZWZ
Entry DOI | 10.2210/pdb4zwz/pdb |
Related | 4ZWX 4ZWY 4ZX0 4ZX1 |
Descriptor | Carbonic anhydrase 2, ZINC ION, methyl (2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfonyl-4-sulfamoyloxy-pyrrolidine-2-carbox ylate, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase ix mimic, glucosyl sulfamate, inhibitor complex., lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29516.58 |
Authors | Mahon, B.P.,Lomelino, C.L.,Driscoll, J.M.,McKenna, R. (deposition date: 2015-05-19, release date: 2015-08-05, Last modification date: 2023-09-27) |
Primary citation | Mahon, B.P.,Lomelino, C.L.,Ladwig, J.,Rankin, G.M.,Driscoll, J.M.,Salguero, A.L.,Pinard, M.A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.,McKenna, R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. J.Med.Chem., 58:6630-6638, 2015 Cited by PubMed: 26203869DOI: 10.1021/acs.jmedchem.5b00845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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