4ZWY

Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor

4ZWY の概要

• エントリーDOI: 10.2210/pdb4zwy/pdb
• 関連するPDBエントリー: 4ZWI 4ZWX 4ZWZ 4ZX0 4ZX1
• 分子名称: Carbonic anhydrase 2, ZINC ION, (6S)-1,3,4,5-tetra-O-acetyl-2,6-anhydro-6-{[5-(sulfamoyloxy)pentyl]sulfamoyl}-L-altritol, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase ii, glucosyl sulfamate, inhibitor complex., lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29666.74

構造登録者

Mahon, B.P.,Lomelino, C.L.,Driscoll, J.M.,McKenna, R. (登録日: 2015-05-19, 公開日: 2015-08-05, 最終更新日: 2023-09-27)

• 主引用文献: Mahon, B.P.,Lomelino, C.L.,Ladwig, J.,Rankin, G.M.,Driscoll, J.M.,Salguero, A.L.,Pinard, M.A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.,McKenna, R.; Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.; J.Med.Chem., 58:6630-6638, 2015; PubMed: 26203869; DOI: 10.1021/acs.jmedchem.5b00845

実験手法

X-RAY DIFFRACTION (1.5 Å)