4ZW1
Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
Summary for 4ZW1
Entry DOI | 10.2210/pdb4zw1/pdb |
Descriptor | Bromodomain-containing protein 4, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, chromatin reader protein, transcription regulation, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 17224.86 |
Authors | |
Primary citation | Liu, B.,Zhang, S.,Guo, M.,Tian, M. Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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