4ZW1

Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer

Summary for 4ZW1

• Entry DOI: 10.2210/pdb4zw1/pdb
• Descriptor: Bromodomain-containing protein 4, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: inhibitor, chromatin reader protein, transcription regulation, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 17224.86

Authors

Liu, B.,Zhang, S.,Guo, M.,Tian, M. (deposition date: 2015-05-19, release date: 2016-06-22, Last modification date: 2024-03-20)

• Primary citation: Liu, B.,Zhang, S.,Guo, M.,Tian, M.; Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)