4ZW1
Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
4ZW1 の概要
エントリーDOI | 10.2210/pdb4zw1/pdb |
分子名称 | Bromodomain-containing protein 4, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
機能のキーワード | inhibitor, chromatin reader protein, transcription regulation, transcription-inhibitor complex, transcription/inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus: O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 17224.86 |
構造登録者 | |
主引用文献 | Liu, B.,Zhang, S.,Guo, M.,Tian, M. Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.75 Å) |
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