4ZW1

Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer

4ZW1 の概要

• エントリーDOI: 10.2210/pdb4zw1/pdb
• 分子名称: Bromodomain-containing protein 4, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, chromatin reader protein, transcription regulation, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17224.86

構造登録者

Liu, B.,Zhang, S.,Guo, M.,Tian, M. (登録日: 2015-05-19, 公開日: 2016-06-22, 最終更新日: 2024-03-20)

• 主引用文献: Liu, B.,Zhang, S.,Guo, M.,Tian, M.; Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer; To Be Published,

実験手法

X-RAY DIFFRACTION (1.75 Å)