4ZTL

Irak4-inhibitor co-structure

Summary for 4ZTL

Entry DOI	10.2210/pdb4ztl/pdb
Related	4ZTM 4ZTN
Descriptor	Interleukin-1 receptor-associated kinase 4, (1R,2S,3R,5R)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol (3 entities in total)
Functional Keywords	kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9NWZ3
Total number of polymer chains	4
Total formula weight	137486.82
Authors	Fischmann, T.O. (deposition date: 2015-05-14, release date: 2015-09-02, Last modification date: 2023-09-27)
Primary citation	Seganish, W.M.,Fischmann, T.O.,Sherborne, B.,Matasi, J.,Lavey, B.,McElroy, W.T.,Tulshian, D.,Tata, J.,Sondey, C.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X. Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors. Acs Med.Chem.Lett., 6:942-947, 2015 Cited by PubMed: 26288698 DOI: 10.1021/acsmedchemlett.5b00279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation