4ZTH

Structure of human p38aMAPK-arylpyridazinylpyridine fragment complex used in inhibitor discovery

4ZTH の概要

• エントリーDOI: 10.2210/pdb4zth/pdb
• 分子名称: Mitogen-activated protein kinase 14, 6-chloro-3-phenyl-4-(pyridin-4-yl)pyridazine, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, ... (5 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44541.00

構造登録者

Grum-Tokars, V.L.,Roy, S.M.,Watterson, D.M. (登録日: 2015-05-14, 公開日: 2016-06-22, 最終更新日: 2024-03-06)

• 主引用文献: Roy, S.M.,Minasov, G.,Arancio, O.,Chico, L.W.,Van Eldik, L.J.,Anderson, W.F.,Pelletier, J.C.,Watterson, D.M.; A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.; J.Med.Chem., 62:5298-5311, 2019; PubMed: 30978288; DOI: 10.1021/acs.jmedchem.9b00058

実験手法

X-RAY DIFFRACTION (2.15 Å)