4ZSY

Pig Brain GABA-AT inactivated by (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic acid.

Summary for 4ZSY

Entry DOI	10.2210/pdb4zsy/pdb
Descriptor	4-aminobutyrate aminotransferase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, (1S)-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-3-ene-1,3-dicarboxylic acid, ... (5 entities in total)
Functional Keywords	gaba aminotransferase, amino-4-fluoromethylenyl-1-cyclopentanoic acid, inactivation, mechanism-based, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Sus scrofa (Pig)
Total number of polymer chains	4
Total formula weight	211107.88
Authors	Wu, R.,Lee, H.,Le, H.V.,Doud, E.,Sanishvili, R.,Compton, P.,Kelleher, N.L.,Silverman, R.B.,Liu, D. (deposition date: 2015-05-14, release date: 2015-07-08, Last modification date: 2024-03-06)
Primary citation	Lee, H.,Le, H.V.,Wu, R.,Doud, E.,Sanishvili, R.,Kellie, J.F.,Compton, P.D.,Pachaiyappan, B.,Liu, D.,Kelleher, N.L.,Silverman, R.B. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Acs Chem.Biol., 10:2087-2098, 2015 Cited by PubMed: 26110556 DOI: 10.1021/acschembio.5b00212 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation