4ZSE

Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II

Summary for 4ZSE

• Entry DOI: 10.2210/pdb4zse/pdb
• Related: 4ZQJ
• Descriptor: Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: egfr, t790m, v948r, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 4
• Total formula weight: 153082.46

Authors

Yan, X.E.,Yun, C.H. (deposition date: 2015-05-13, release date: 2016-06-15, Last modification date: 2023-11-08)

• Primary citation: Wu, H.,Wang, A.,Zhang, W.,Wang, B.,Wang, B.,Yan, X.E.,Chen, C.,Hu, C.,Ye, Z.,Zhao, Z.,Wang, L.,Li, X.,Yu, K.,Liu, J.,Wu, J.,Wang, J.,Wang, C.,Weisberg, E.L.,Liu, J.,Gray, N.S.,Chen, L.,Yun, C.H.,Liu, Q.; Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)