Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II

Summary for 4ZSE

DescriptorEpidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsegfr, t790m, v948r, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted P00533
Total number of polymer chains4
Total molecular weight153082.46
Yan, X.E.,Yun, C.H. (deposition date: 2015-05-13, release date: 2016-06-15)
Primary citation
Wu, H.,Wang, A.,Zhang, W.,Wang, B.,Wang, B.,Yan, X.E.,Chen, C.,Hu, C.,Ye, Z.,Zhao, Z.,Wang, L.,Li, X.,Yu, K.,Liu, J.,Wu, J.,Wang, J.,Wang, C.,Weisberg, E.L.,Liu, J.,Gray, N.S.,Chen, L.,Yun, C.H.,Liu, Q.
Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2131506.6%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report