4ZSA

Crystal structure of FGFR1 kinase domain in complex with 7n

4ZSA の概要

• エントリーDOI: 10.2210/pdb4zsa/pdb
• 分子名称: Fibroblast growth factor receptor 1, 4-(4-ethylpiperazin-1-yl)-N-[6-(3-methoxyphenyl)-2H-indazol-3-yl]benzamide (3 entities in total)
• 機能のキーワード: fgfr1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71067.67

構造登録者

Liu, Q.F.,Xu, Y.C. (登録日: 2015-05-13, 公開日: 2015-06-17, 最終更新日: 2023-11-08)

• 主引用文献: Liu, J.,Peng, X.,Dai, Y.,Zhang, W.,Ren, S.,Ai, J.,Geng, M.,Li, Y.; Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.; Org.Biomol.Chem., 13:7643-7654, 2015; PubMed: 26080733; DOI: 10.1039/c5ob00778j

実験手法

X-RAY DIFFRACTION (2 Å)