4ZS0

Human Aurora A catalytic domain bound to SB-6-OH

Summary for 4ZS0

Entry DOI	10.2210/pdb4zs0/pdb
Descriptor	Aurora kinase A, 5-hydroxy-1'H-1,2'-bibenzimidazol-2(3H)-one (2 entities in total)
Functional Keywords	aurora, kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	33215.04
Authors	Marcaida, M.J.,Kilchmann, F.,Schick, T.,Reymond, J.L. (deposition date: 2015-05-12, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Kilchmann, F.,Marcaida, M.J.,Kotak, S.,Schick, T.,Boss, S.D.,Awale, M.,Gonczy, P.,Reymond, J.L. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. J.Med.Chem., 59:7188-7211, 2016 Cited by PubMed: 27391133 DOI: 10.1021/acs.jmedchem.6b00709 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation