4ZRO
2.1 A X-Ray Structure of FIPV-3CLpro bound to covalent inhibitor
Summary for 4ZRO
Entry DOI | 10.2210/pdb4zro/pdb |
Related PRD ID | PRD_002174 |
Descriptor | 3C-like proteinase, Bounded inhibitor of N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-{(2S)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-leucinamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | coronavirus, main protease, 3clpro, mpro, fipv, fcov, inhibitor complex, feline infectious peritonitis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) More |
Total number of polymer chains | 8 |
Total formula weight | 133587.53 |
Authors | St John, S.E.,Mesecar, A.D. (deposition date: 2015-05-12, release date: 2015-10-14, Last modification date: 2019-12-11) |
Primary citation | St John, S.E.,Therkelsen, M.D.,Nyalapatla, P.R.,Osswald, H.L.,Ghosh, A.K.,Mesecar, A.D. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. Bioorg.Med.Chem.Lett., 25:5072-5077, 2015 Cited by PubMed: 26592814DOI: 10.1016/j.bmcl.2015.10.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.0566 Å) |
Structure validation
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