4ZQK

Structure of the complex of human programmed death-1 (PD-1) and its ligand PD-L1.

Summary for 4ZQK

• Entry DOI: 10.2210/pdb4zqk/pdb
• Descriptor: Programmed cell death 1 ligand 1, Programmed cell death protein 1, SODIUM ION, ... (4 entities in total)
• Functional Keywords: complex, co-stimulation, receptor-ligand complex, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein: Q9NZQ7; Membrane; Single-pass type I membrane protein: Q15116
• Total number of polymer chains: 2
• Total formula weight: 26385.79

Authors

Zak, K.M.,Dubin, G.,Holak, T.A. (deposition date: 2015-05-10, release date: 2015-11-04, Last modification date: 2024-10-16)

Primary citation

Zak, K.M.,Kitel, R.,Przetocka, S.,Golik, P.,Guzik, K.,Musielak, B.,Domling, A.,Dubin, G.,Holak, T.A.
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.
Structure, 23:2341-2348, 2015

PubMed Abstract: Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types of cancer. Small-molecule drugs interfering with this pathway are highly awaited, but their development is hindered by insufficient structural information. This study reveals the molecular details of the human PD-1/PD-L1 interaction based on an X-ray structure of the complex. First, it is shown that the ligand binding to human PD-1 is associated with significant plasticity within the receptor. Second, a detailed molecular map of the interaction surface is provided, allowing definition of the regions within both interacting partners that may likely be targeted by small molecules.

PubMed: 26602187
DOI: 10.1016/j.str.2015.09.010

Experimental method

X-RAY DIFFRACTION (2.45 Å)