4ZKV

Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A at P21 space group

4ZKV の概要

• エントリーDOI: 10.2210/pdb4zkv/pdb
• 関連するPDBエントリー: 1KPC
• 分子名称: Histidine triad nucleotide-binding protein 1, SULFATE ION (3 entities in total)
• 機能のキーワード: hint, hit, histidine triad, hydrolase, phosphoramidase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P49773
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 55487.85

構造登録者

Dolot, R.M.,Seda, A.,Nawrot, B. (登録日: 2015-04-30, 公開日: 2016-03-02, 最終更新日: 2024-01-10)

主引用文献

Dolot, R.,Kaczmarek, R.,Seda, A.,Krakowiak, A.,Baraniak, J.,Nawrot, B.
Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Int.J.Biol.Macromol., 87:62-69, 2016

PubMed Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine triad proteins superfamily. HINT1 plays an important role in various biological processes, and it has been found in many species. Here, we report the first structure (at a 2.34Å resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal. In addition, the apo form of hHINT1 at the space group P21 refined to 1.92Å is reported for comparative studies.

PubMed: 26905466
DOI: 10.1016/j.ijbiomac.2016.02.047

実験手法

X-RAY DIFFRACTION (1.92 Å)