4ZK5

MAP4K4 in complex with inhibitor GNE-495

Summary for 4ZK5

Entry DOI	10.2210/pdb4zk5/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : O95819
Total number of polymer chains	2
Total formula weight	76365.12
Authors	Harris, S.F.,Wu, P.,Coons, M. (deposition date: 2015-04-29, release date: 2015-09-02, Last modification date: 2024-03-06)
Primary citation	Ndubaku, C.O.,Crawford, T.D.,Chen, H.,Boggs, J.W.,Drobnick, J.,Harris, S.F.,Jesudason, R.,McNamara, E.,Nonomiya, J.,Sambrone, A.,Schmidt, S.,Smyczek, T.,Vitorino, P.,Wang, L.,Wu, P.,Yeung, S.,Chen, J.,Chen, K.,Ding, C.Z.,Wang, T.,Xu, Z.,Gould, S.E.,Murray, L.J.,Ye, W. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Acs Med.Chem.Lett., 6:913-918, 2015 Cited by PubMed: 26288693 DOI: 10.1021/acsmedchemlett.5b00174 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation