4ZK5

MAP4K4 in complex with inhibitor GNE-495

4ZK5 の概要

• エントリーDOI: 10.2210/pdb4zk5/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : O95819
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76365.12

構造登録者

Harris, S.F.,Wu, P.,Coons, M. (登録日: 2015-04-29, 公開日: 2015-09-02, 最終更新日: 2024-03-06)

• 主引用文献: Ndubaku, C.O.,Crawford, T.D.,Chen, H.,Boggs, J.W.,Drobnick, J.,Harris, S.F.,Jesudason, R.,McNamara, E.,Nonomiya, J.,Sambrone, A.,Schmidt, S.,Smyczek, T.,Vitorino, P.,Wang, L.,Wu, P.,Yeung, S.,Chen, J.,Chen, K.,Ding, C.Z.,Wang, T.,Xu, Z.,Gould, S.E.,Murray, L.J.,Ye, W.; Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.; Acs Med.Chem.Lett., 6:913-918, 2015; PubMed: 26288693; DOI: 10.1021/acsmedchemlett.5b00174

実験手法

X-RAY DIFFRACTION (2.89 Å)