4ZJ8
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Summary for 4ZJ8
Entry DOI | 10.2210/pdb4zj8/pdb |
Related | 4ZJC |
Descriptor | human OX1R fusion protein to P.abysii glycogen synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID, ... (4 entities in total) |
Functional Keywords | orexin, suvorexant, sb674042, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: O43613 |
Total number of polymer chains | 1 |
Total formula weight | 64830.72 |
Authors | Yin, J.,Brautigam, C.A.,Shao, Z.,Clark, L.,Harrell, C.M.,Gotter, A.L.,Coleman, P.,Renger, J.J.,Rosenbaum, D.M. (deposition date: 2015-04-29, release date: 2016-03-09, Last modification date: 2023-09-27) |
Primary citation | Yin, J.,Babaoglu, K.,Brautigam, C.A.,Clark, L.,Shao, Z.,Scheuermann, T.H.,Harrell, C.M.,Gotter, A.L.,Roecker, A.J.,Winrow, C.J.,Renger, J.J.,Coleman, P.J.,Rosenbaum, D.M. Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nat.Struct.Mol.Biol., 23:293-299, 2016 Cited by PubMed: 26950369DOI: 10.1038/nsmb.3183 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.751 Å) |
Structure validation
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