4ZBI
Mcl-1 complexed with small molecules
Summary for 4ZBI
| Entry DOI | 10.2210/pdb4zbi/pdb |
| Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid (3 entities in total) |
| Functional Keywords | inhibitor, complex, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 12 |
| Total formula weight | 218828.83 |
| Authors | Zhao, B. (deposition date: 2015-04-14, release date: 2015-04-29, Last modification date: 2024-03-06) |
| Primary citation | Burke, J.P.,Bian, Z.,Shaw, S.,Zhao, B.,Goodwin, C.M.,Belmar, J.,Browning, C.F.,Vigil, D.,Friberg, A.,Camper, D.V.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58:3794-3805, 2015 Cited by PubMed: 25844895DOI: 10.1021/jm501984f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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