4ZBI

Mcl-1 complexed with small molecules

4ZBI の概要

• エントリーDOI: 10.2210/pdb4zbi/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid (3 entities in total)
• 機能のキーワード: inhibitor, complex, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 218828.83

構造登録者

Zhao, B. (登録日: 2015-04-14, 公開日: 2015-04-29, 最終更新日: 2024-03-06)

• 主引用文献: Burke, J.P.,Bian, Z.,Shaw, S.,Zhao, B.,Goodwin, C.M.,Belmar, J.,Browning, C.F.,Vigil, D.,Friberg, A.,Camper, D.V.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.; Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.; J.Med.Chem., 58:3794-3805, 2015; PubMed: 25844895; DOI: 10.1021/jm501984f

実験手法

X-RAY DIFFRACTION (2.5 Å)