4ZAE

Development of a novel class of potent and selective FIXa inhibitors

Summary for 4ZAE

• Entry DOI: 10.2210/pdb4zae/pdb
• Descriptor: Coagulation factor IX, 2,6-dichloro-N-[(2R)-2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ... (6 entities in total)
• Functional Keywords: serine proteinase, blood coagulation, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P00740 P00740
• Total number of polymer chains: 2
• Total formula weight: 33682.19

Authors

Hruza, A.,Reichert, P. (deposition date: 2015-04-13, release date: 2015-06-03, Last modification date: 2023-09-27)

• Primary citation: Zhang, T.,Andre, P.,Bateman, T.J.,Chen, Y.H.,Desai, K.,Ellsworth, K.,Geissler, W.M.,Guo, L.,Hruza, A.,Jian, T.,Meng, D.,Parker, D.L.,Qian, X.,Reichert, P.,Sherer, E.C.,Shu, M.,Smith, C.J.,Sonatore, L.M.,Tschirret-Guth, R.,Nolting, A.F.,Orr, R.,Campeau, L.C.,Araki, K.,Nishimura, T.,Sakurada, I.,Wood, H.B.; Development of a novel class of potent and selective FIXa inhibitors.; Bioorg.Med.Chem.Lett., 25:4945-4949, 2015; PubMed: 25978966; DOI: 10.1016/j.bmcl.2015.04.057

Experimental method

X-RAY DIFFRACTION (1.86 Å)