4Z7P

X-ray structure of racemic ShK Q16K toxin

Summary for 4Z7P

Entry DOI	10.2210/pdb4z7p/pdb
Related	4LFS
Descriptor	Potassium channel toxin kappa-stichotoxin-She1a, SULFATE ION (3 entities in total)
Functional Keywords	shk toxin, toxin
Biological source	Stoichactis helianthus (Carribean sea anemone)
Cellular location	Secreted: P29187
Total number of polymer chains	1
Total formula weight	4551.26
Authors	Sickmier, E.A. (deposition date: 2015-04-07, release date: 2015-09-09, Last modification date: 2015-09-23)
Primary citation	Murray, J.K.,Qian, Y.X.,Liu, B.,Elliott, R.,Aral, J.,Park, C.,Zhang, X.,Stenkilsson, M.,Salyers, K.,Rose, M.,Li, H.,Yu, S.,Andrews, K.L.,Colombero, A.,Werner, J.,Gaida, K.,Sickmier, E.A.,Miu, P.,Itano, A.,McGivern, J.,Gegg, C.V.,Sullivan, J.K.,Miranda, L.P. Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J.Med.Chem., 58:6784-6802, 2015 Cited by PubMed: 26288216 DOI: 10.1021/acs.jmedchem.5b00495 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation