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4Z35

Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539

Summary for 4Z35
Entry DOI10.2210/pdb4z35/pdb
Related4Z34 4Z36
DescriptorLysophosphatidic acid receptor 1,Soluble cytochrome b562, 3-{1-[(2S,3S)-3-(4-acetyl-3,5-dimethoxyphenyl)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1H-pyrrol-3-yl}propanoic acid, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, ... (4 entities in total)
Functional Keywordshuman lysophosphatidic acid receptor 1 (lpa1), g-protein coupled receptor (gpcr), membrane protein, antagonist, endogenous ligand, psi-biology, structural genomics, gpcr network, lipidic cubic phase (lcp), compound design, polypharmacology, lipid receptor, transport protein-inhibitor complex, transport protein/inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationCell surface : Q92633
Total number of polymer chains1
Total formula weight53478.29
Authors
Primary citationChrencik, J.E.,Roth, C.B.,Terakado, M.,Kurata, H.,Omi, R.,Kihara, Y.,Warshaviak, D.,Nakade, S.,Asmar-Rovira, G.,Mileni, M.,Mizuno, H.,Griffith, M.T.,Rodgers, C.,Han, G.W.,Velasquez, J.,Chun, J.,Stevens, R.C.,Hanson, M.A.
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Cell, 161:1633-1643, 2015
Cited by
PubMed: 26091040
DOI: 10.1016/j.cell.2015.06.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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