4Z34

Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO9780307

Summary for 4Z34

• Entry DOI: 10.2210/pdb4z34/pdb
• Related: 4Z35 4Z36
• Descriptor: Lysophosphatidic acid receptor 1, Soluble cytochrome b562, {1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1 H-pyrrol-3-yl}acetic acid, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate (3 entities in total)
• Functional Keywords: human lysophosphatidic acid receptor 1 (lpa1), g-protein coupled receptor (gpcr), membrane protein, antagonist, endogenous ligand, psi-biology, structural genomics, gpcr network, lipidic cubic phase (lcp), compound design, polypharmacology, lipid receptor, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell surface : Q92633
• Total number of polymer chains: 1
• Total formula weight: 53436.25

Authors

Chrencik, J.E.,Roth, C.B.,Terakado, M.,Kurata, H.,Omi, R.,Kihara, Y.,Warshaviak, D.,Nakade, S.,Asmar-Rovira, G.,Mileni, M.,Mizuno, H.,Griffith, M.T.,Rodgers, C.,Han, G.W.,Velasquez, J.,Chun, J.,Stevens, R.C.,Hanson, M.A.,GPCR Network (GPCR) (deposition date: 2015-03-30, release date: 2015-06-03, Last modification date: 2023-09-27)

• Primary citation: Chrencik, J.E.,Roth, C.B.,Terakado, M.,Kurata, H.,Omi, R.,Kihara, Y.,Warshaviak, D.,Nakade, S.,Asmar-Rovira, G.,Mileni, M.,Mizuno, H.,Griffith, M.T.,Rodgers, C.,Han, G.W.,Velasquez, J.,Chun, J.,Stevens, R.C.,Hanson, M.A.; Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.; Cell, 161:1633-1643, 2015; PubMed: 26091040; DOI: 10.1016/j.cell.2015.06.002

Experimental method

X-RAY DIFFRACTION (3 Å)