4Z2G

Serratia marcescens Chitinase B complexed with macrolide inhibitor 26

4Z2G の概要

• エントリーDOI: 10.2210/pdb4z2g/pdb
• 関連するPDBエントリー: 3WD0 4Z2H 4Z2I 4Z2J 4Z2K 4Z2L
• 分子名称: Chitinase B, (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ethyl-2,10-dihydroxy-2,6,8,10,12,15,15,17-octamethyl-5-oxo-9-(prop-2-yn-1-yloxy)-4,14,16-trioxabicyclo[11.3.1]heptadec-7-yl {4-[N'-(methylcarbamoyl)carbamimidamido]butyl}carbamate (3 entities in total)
• 機能のキーワード: chitinase, inhibitor, macrolide, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Serratia marcescens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57349.17

構造登録者

Maita, N.,Sugawara, A.,Sunazuka, T. (登録日: 2015-03-30, 公開日: 2015-07-01, 最終更新日: 2023-11-08)

• 主引用文献: Sugawara, A.,Maita, N.,Gouda, H.,Yamamoto, T.,Hirose, T.,Kimura, S.,Saito, Y.,Nakano, H.,Kasai, T.,Nakano, H.,Shiomi, K.,Hirono, S.,Watanabe, T.,Taniguchi, H.,Omura, S.,Sunazuka, T.; Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase; J.Med.Chem., 58:4984-4997, 2015; PubMed: 26030312; DOI: 10.1021/acs.jmedchem.5b00175

実験手法

X-RAY DIFFRACTION (2.6 Å)