4Z24

Mimivirus R135 (residues 51-702)

4Z24 の概要

• エントリーDOI: 10.2210/pdb4z24/pdb
• 関連するPDBエントリー: 4Z25 4Z26
• 分子名称: GMC-type oxidoreductase R135, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: gmc oxidoreductase, fad, fiber, oxidoreductase
• 由来する生物種: Acanthamoeba polyphaga mimivirus (APMV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 144281.96

構造登録者

Klose, T.,Rossmann, M.G. (登録日: 2015-03-28, 公開日: 2015-04-15, 最終更新日: 2023-09-27)

主引用文献

Klose, T.,Herbst, D.A.,Zhu, H.,Max, J.P.,Kenttamaa, H.I.,Rossmann, M.G.
A Mimivirus Enzyme that Participates in Viral Entry.
Structure, 23:1058-1065, 2015

PubMed Abstract: Mimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba. The structure of R135, a major component of the fibrous outer layer of Mimivirus, has been determined to 2-Å resolution. The protein's structure is similar to that of members of the glucose-methanol-choline oxidoreductase family, which have an N-terminal FAD binding domain and a C-terminal substrate recognition domain. The closest homolog to R135 is an aryl-alcohol oxidase that participates in lignin biodegradation of plant cell walls. Thus R135 might participate in the degradation of their normal hosts, including some lignin-containing algae.

PubMed: 25982526
DOI: 10.1016/j.str.2015.03.023

実験手法

X-RAY DIFFRACTION (2 Å)