4Z1N
Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
Summary for 4Z1N
Entry DOI | 10.2210/pdb4z1n/pdb |
Related | 4Z0Q 4Z1E 4Z1J 4Z1K |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)carbonyl]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | lyase, carbonate dehydratase ii, carbonic anhydrase c, carbonic anhydrase ii, ca-ii, carbonate dehydratase ii- inhibitor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29512.62 |
Authors | Brynda, J.,Pospisilova, K.,Rezacova, P.,Pachl, P. (deposition date: 2015-03-27, release date: 2015-08-26, Last modification date: 2024-05-08) |
Primary citation | Buemi, M.R.,De Luca, L.,Ferro, S.,Bruno, E.,Ceruso, M.,Supuran, C.T.,Pospisilova, K.,Brynda, J.,Rezacova, P.,Gitto, R. Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102:223-232, 2015 Cited by PubMed: 26276436DOI: 10.1016/j.ejmech.2015.07.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
Download full validation report